Citation 84206

KOGUCHI,Y: KOHNO,J: SUZUKI,SI: NISHIO,M: TAKAHASHI,K: OHNUKI,T: KOMATSUBARA,S:. (1999). TMC-86A, B AND TMC-96, NEW PROTEASOME INHIBITORS FROM STREPTOMYCES SP. TC 1084 AND SACCHAROTHRIX SP. TC 1094. I. TAXONOMY, FERMENTATION, ISOLATION, AND BIOLOGICAL ACTIVITIES.. 52(12)

Citation Details

Title	TMC-86A, B AND TMC-96, NEW PROTEASOME INHIBITORS FROM STREPTOMYCES SP. TC 1084 AND SACCHAROTHRIX SP. TC 1094. I. TAXONOMY, FERMENTATION, ISOLATION, AND BIOLOGICAL ACTIVITIES.
Authors	KOGUCHI,Y: KOHNO,J: SUZUKI,SI: NISHIO,M: TAKAHASHI,K: OHNUKI,T: KOMATSUBARA,S:
Year	1999
Volume	52
Issue	12

Summary

Year: 1999

Journal: Unknown

Organisms and Their Experiments (2)

Saccharothrix species (TO BE DETERMINED)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	QUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	SACCHAROTHRIX ANTIBIOTIC TMC-96	None
2	CHYMOTRYPSIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SACCHAROTHRIX ANTIBIOTIC TMC-96	ACTIVE
3	PEPTIDYLGLUTAMYLPEPTIDE HYDROLYSIS INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SACCHAROTHRIX ANTIBIOTIC TMC-96	ACTIVE
4	TRYPSIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SACCHAROTHRIX ANTIBIOTIC TMC-96	WEAK ACTIVITY
5	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	SACCHAROTHRIX ANTIBIOTIC TMC-96	ACTIVE
6	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	SACCHAROTHRIX ANTIBIOTIC TMC-96	ACTIVE
7	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	SACCHAROTHRIX ANTIBIOTIC TMC-96	ACTIVE
8	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	SACCHAROTHRIX ANTIBIOTIC TMC-96	ACTIVE
9	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	SACCHAROTHRIX ANTIBIOTIC TMC-96	ACTIVE
10	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	SACCHAROTHRIX ANTIBIOTIC TMC-96	ACTIVE
11	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	SACCHAROTHRIX ANTIBIOTIC TMC-96	ACTIVE

Streptomyces species (STREPTOMYCETACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	QUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	STREPTOMYCES ANTIBIOTIC TMC=86-A	None
2	CHYMOTRYPSIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	STREPTOMYCES ANTIBIOTIC TMC=86-A	ACTIVE
3	PEPTIDYLGLUTAMYLPEPTIDE HYDROLYSIS INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	STREPTOMYCES ANTIBIOTIC TMC=86-A	ACTIVE
4	TRYPSIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	STREPTOMYCES ANTIBIOTIC TMC=86-A	WEAK ACTIVITY
5	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	STREPTOMYCES ANTIBIOTIC TMC=86-A	ACTIVE
6	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	STREPTOMYCES ANTIBIOTIC TMC=86-A	ACTIVE
7	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	STREPTOMYCES ANTIBIOTIC TMC=86-A	ACTIVE
8	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	STREPTOMYCES ANTIBIOTIC TMC=86-A	ACTIVE
9	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	STREPTOMYCES ANTIBIOTIC TMC=86-A	ACTIVE
10	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	STREPTOMYCES ANTIBIOTIC TMC=86-A	ACTIVE
11	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	STREPTOMYCES ANTIBIOTIC TMC=86-A	ACTIVE
12	Not specified	QUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	STREPTOMYCES ANTIBIOTIC TMC-86-B	None
13	CHYMOTRYPSIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	STREPTOMYCES ANTIBIOTIC TMC-86-B	ACTIVE
14	PEPTIDYLGLUTAMYLPEPTIDE HYDROLYSIS INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	STREPTOMYCES ANTIBIOTIC TMC-86-B	WEAK ACTIVITY
15	TRYPSIN INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	STREPTOMYCES ANTIBIOTIC TMC-86-B	WEAK ACTIVITY
16	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	STREPTOMYCES ANTIBIOTIC TMC-86-B	ACTIVE
17	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	STREPTOMYCES ANTIBIOTIC TMC-86-B	ACTIVE
18	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	STREPTOMYCES ANTIBIOTIC TMC-86-B	ACTIVE
19	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	STREPTOMYCES ANTIBIOTIC TMC-86-B	ACTIVE
20	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	STREPTOMYCES ANTIBIOTIC TMC-86-B	ACTIVE
21	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	STREPTOMYCES ANTIBIOTIC TMC-86-B	ACTIVE
22	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	STREPTOMYCES ANTIBIOTIC TMC-86-B	ACTIVE